MIKROGRANUL MUKOADHESIF EKSTRAK DAUN SALAM (Syzygium polyanthum (Wight.)) DENGAN PERBEDAAN POLIMER HPMC DAN KITOSAN

Bay leaf (Syzygium polyanthum (Wight.) contains polyphenolic compounds that are beneficial in the treatment of hypercholesterolemia by reducing Low Density Lipoprotein (LDL) levels. The dosage form mucoadhesive microgranules is able to prolong active substance contact time with mucosa give better therapeutic effect. This study aims make bay extract different polymers Hydroxy Propyl Methyl Cellulose (HPMC) and chitosan. There were 4 formulas, namely formula I (25% HPMC), II (30% III chitosan) IV chitosan). Microgranules prepared wet granulation method. Microgranule test parameters include moisture content, flow rate, angle repose, particle size, total polyphenol wash off morphology test. results this showed all formulas had water content <5%, rate repose including easy flow. size was range 48.7 – 637 μm a 4.15 4.27%. stomach 1.33 - 3.23% (31.97 75.63%) intestine 1.26 3.76% (27.95 88.03%). best used 30% HPMC polymer.